Artemether-Soluplus Hot-Melt Extrudate Solid Dispersion Systems for Solubility and Dissolution Rate Enhancement with Amorphous State Characteristics

This work studied artemether (ARTM) solid dispersion (SD) formulation using mixture of polymer excipient Soluplus, PEG 400, Lutrol F127, and Lutrol F68 melts at temperatures lower than the melting point of ARTM using a laboratory-size, single-screw rotating batch extruder. The effects of three surfa...

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Bibliografiske detaljer
Udgivet i:J Pharm (Cairo)
Main Authors: Fule, Ritesh A., Meer, Tarique S., Sav, Ajay R., Amin, Purnima D.
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi Publishing Corporation 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590813/
https://ncbi.nlm.nih.gov/pubmed/26555968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/151432
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