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Programming cells by multiplex genome engineering and accelerated evolution

The breadth of genomic diversity found among organisms in nature allows populations to adapt to diverse environments(1,2). However, genomic diversity is difficult to generate in the laboratory and new phenotypes do not easily arise on practical timescales(3). Although in vitro and directed evolution...

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Библиографические подробности
Опубликовано в: :Nature
Главные авторы: Wang, Harris H., Isaacs, Farren J., Carr, Peter A., Sun, Zachary Z., Xu, George, Forest, Craig R., Church, George M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590770/
https://ncbi.nlm.nih.gov/pubmed/19633652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08187
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