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Programming cells by multiplex genome engineering and accelerated evolution

The breadth of genomic diversity found among organisms in nature allows populations to adapt to diverse environments(1,2). However, genomic diversity is difficult to generate in the laboratory and new phenotypes do not easily arise on practical timescales(3). Although in vitro and directed evolution...

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Bibliografski detalji
Izdano u:Nature
Glavni autori: Wang, Harris H., Isaacs, Farren J., Carr, Peter A., Sun, Zachary Z., Xu, George, Forest, Craig R., Church, George M.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590770/
https://ncbi.nlm.nih.gov/pubmed/19633652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08187
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