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Inferring synthetic lethal interactions from mutual exclusivity of genetic events in cancer
BACKGROUND: Synthetic lethality (SL) refers to the genetic interaction between two or more genes where only their co-alteration (e.g. by mutations, amplifications or deletions) results in cell death. In recent years, SL has emerged as an attractive therapeutic strategy against cancer: by targeting t...
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| Publicado no: | Biol Direct |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4590705/ https://ncbi.nlm.nih.gov/pubmed/26427375 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13062-015-0086-1 |
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