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Bioinspired genotype–phenotype linkages: mimicking cellular compartmentalization for the engineering of functional proteins

The idea of compartmentalization of genotype and phenotype in cells is key for enabling Darwinian evolution. This contribution describes bioinspired systems that use in vitro compartments—water-in-oil droplets and gel-shell beads—for the directed evolution of functional proteins. Technologies based...

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Veröffentlicht in:Interface Focus
Hauptverfasser: van Vliet, Liisa D., Colin, Pierre-Yves, Hollfelder, Florian
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Royal Society 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590426/
https://ncbi.nlm.nih.gov/pubmed/26464791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsfs.2015.0035
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