Increased sMICA and TGFβ(1) levels in HNSCC patients impair NKG2D-dependent functionality of activated NK cells

Disseminated head-and-neck squamous cell carcinoma (HNSCC) escapes immune surveillance and thus frequently manifests as fatal disease. Here, we report on the distribution of distinct immune cell subpopulations, natural killer (NK) cell cytotoxicity and tumor immune escape mechanisms (TIEMs) in 55 HN...

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Publicat a:Oncoimmunology
Autors principals: Klöß, Stephan, Chambron, Nicole, Gardlowski, Tanja, Arseniev, Lubomir, Koch, Joachim, Esser, Ruth, Glienke, Wolfgang, Seitz, Oliver, Köhl, Ulrike
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2015
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589991/
https://ncbi.nlm.nih.gov/pubmed/26451327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1055993
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