mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

Senescent cells secrete a combination of factors collectively known as the senescence-associated secretory phenotype (SASP). The SASP reinforces senescence and activates an immune surveillance response but it can also display pro-tumorigenic properties and contribute to age-related pathologies. In a...

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Gepubliceerd in:Nat Cell Biol
Hoofdauteurs: Herranz, Nicolás, Gallage, Suchira, Mellone, Massimiliano, Wuestefeld, Torsten, Klotz, Sabrina, Hanley, Christopher J., Raguz, Selina, Acosta, Juan Carlos, Innes, Andrew J, Banito, Ana, Georgilis, Athena, Montoya, Alex, Wolter, Katharina, Dharmalingam, Gopuraja, Faull, Peter, Carroll, Thomas, Martínez-Barbera, Juan Pedro, Cutillas, Pedro, Reisinger, Florian, Heikenwalder, Mathias, Miller, Richard A., Withers, Dominic, Zender, Lars, Thomas, Gareth J., Gil, Jesús
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589897/
https://ncbi.nlm.nih.gov/pubmed/26280535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3225
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