SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer

Oncogene-induced senescence (OIS) is a potent tumor suppressor mechanism. To identify senescence regulators relevant to cancer, we screened an shRNA library targeting genes deleted in hepatocellular carcinoma (HCC). Here, we describe how knockdown of the SWI/SNF component ARID1B prevents OIS and coo...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Tordella, Luca, Khan, Sadaf, Hohmeyer, Anja, Banito, Ana, Klotz, Sabrina, Raguz, Selina, Martin, Nadine, Dhamarlingam, Gopuraja, Carroll, Thomas, González Meljem, José Mario, Deswal, Sumit, Martínez-Barbera, Juan Pedro, García-Escudero, Ramón, Zuber, Johannes, Zender, Lars, Gil, Jesús
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5088567/
https://ncbi.nlm.nih.gov/pubmed/27737960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.286112.116
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