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SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer
Oncogene-induced senescence (OIS) is a potent tumor suppressor mechanism. To identify senescence regulators relevant to cancer, we screened an shRNA library targeting genes deleted in hepatocellular carcinoma (HCC). Here, we describe how knockdown of the SWI/SNF component ARID1B prevents OIS and coo...
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| Publicado no: | Genes Dev |
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| Main Authors: | , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5088567/ https://ncbi.nlm.nih.gov/pubmed/27737960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.286112.116 |
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