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Activation of the AMPK-ULK1 pathway plays an important role in autophagy during prion infection
AMPK is a serine/threonine protein kinase that acts as a positive regulator of autophagy, by phosphorylating ULK1 at specific sites. A previous study demonstrated activation of the macroautophagic system in scrapie-infected experimental rodents and in certain human prion diseases, in which the essen...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4589734/ https://ncbi.nlm.nih.gov/pubmed/26423766 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14728 |
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