Activation of the AMPK-ULK1 pathway plays an important role in autophagy during prion infection

AMPK is a serine/threonine protein kinase that acts as a positive regulator of autophagy, by phosphorylating ULK1 at specific sites. A previous study demonstrated activation of the macroautophagic system in scrapie-infected experimental rodents and in certain human prion diseases, in which the essen...

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Pubblicato in:Sci Rep
Autori principali: Fan, Xue-Yu, Tian, Chan, Wang, Hui, Xu, Yin, Ren, Ke, Zhang, Bao-Yun, Gao, Chen, Shi, Qi, Meng, Ge, Zhang, Lu-Bin, Zhao, Yang-Jing, Shao, Qi-Xiang, Dong, Xiao-Ping
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589734/
https://ncbi.nlm.nih.gov/pubmed/26423766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14728
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