PD-L1 mAb Treats Ischemic Stroke by Controlling CNS Inflammation

BACKGROUND AND PURPOSE: Both pathogenic and regulatory immune processes are involved in the middle cerebral artery occlusion (MCAO) model of experimental stroke, including interactions involving the Programmed Death 1 (PD-1) receptor and its two ligands, PD-L1 and PD-L2. Although PD-1 reduced stroke...

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Pubblicato in:Stroke
Autori principali: Bodhankar, Sheetal, Chen, Yingxin, Lapato, Andrew, Dotson, Abby L., Wang, Jianming, Vandenbark, Arthur A., Saugstad, Julie A., Offner, Halina
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589506/
https://ncbi.nlm.nih.gov/pubmed/26306753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.115.010592
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