Targeting immune co-stimulatory effects of PD-L1 and PD-L2 might represent an effective therapeutic strategy in stroke

Stroke outcome is worsened by the infiltration of inflammatory immune cells into ischemic brains. Our recent study demonstrated that PD-L1- and to a lesser extent PD-L2-deficient mice had smaller brain infarcts and fewer brain-infiltrating cells vs. wild-type (WT) mice, suggesting a pathogenic role...

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Bibliografiska uppgifter
Huvudupphovsmän: Bodhankar, Sheetal, Chen, Yingxin, Lapato, Andrew, Vandenbark, Arthur A., Murphy, Stephanie J., Offner, Halina
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2014
Ämnen:
Neuroscience
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4127946/
https://ncbi.nlm.nih.gov/pubmed/25157219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00228
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