Alternative splicing of the cell-fate determinant Numb in hepatocellular carcinoma

BACKGROUND: The cell fate determinant Numb is aberrantly expressed in cancer. Numb is alternatively spliced with one isoform containing an extended proline rich region (PRR(L)) compared to the other (PRR(S)). PRR(L) was recently reported to enhance proliferation of breast and lung cancer cells. Howe...

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Publicado no:Hepatology
Main Authors: Lu, Yin Ying, Xu, Wanping, Ji, Junfang, Feng, Dechun, Sourbier, Carole, Yang, Youfeng, Qu, Jianhui, Zeng, Zhen, Wang, Chunping, Chang, Xiujuan, Chen, Yan, Mishra, Alok, Xu, Max, Lee, Min-Jung, Lee, Sunmin, Trepel, Jane, Linehan, W. Marston, Wang, Xin Wei, Yang, Yongping, Neckers, Len
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589429/
https://ncbi.nlm.nih.gov/pubmed/26058814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27923
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