Alternative splicing of the cell-fate determinant Numb in hepatocellular carcinoma

BACKGROUND: The cell fate determinant Numb is aberrantly expressed in cancer. Numb is alternatively spliced with one isoform containing an extended proline rich region (PRR(L)) compared to the other (PRR(S)). PRR(L) was recently reported to enhance proliferation of breast and lung cancer cells. Howe...

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Bibliographische Detailangaben
Veröffentlicht in:Hepatology
Hauptverfasser: Lu, Yin Ying, Xu, Wanping, Ji, Junfang, Feng, Dechun, Sourbier, Carole, Yang, Youfeng, Qu, Jianhui, Zeng, Zhen, Wang, Chunping, Chang, Xiujuan, Chen, Yan, Mishra, Alok, Xu, Max, Lee, Min-Jung, Lee, Sunmin, Trepel, Jane, Linehan, W. Marston, Wang, Xin Wei, Yang, Yongping, Neckers, Len
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589429/
https://ncbi.nlm.nih.gov/pubmed/26058814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27923
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