Forkhead Transcription Factor FOXO1 Is Regulated by Both a Stimulatory Thyrotropin Receptor Antibody and Insulin-Like Growth Factor-1 in Orbital Fibroblasts from Patients with Graves' Ophthalmopathy

Background: Activation of thyrotropin receptor (TSHR) and/or insulin-like growth factor (IGF-1) receptor (IGF-1R) enhances HA production and adipogenesis in orbital fibroblasts from patients with Graves' ophthalmopathy (GO) and recapitulates the tissue remodeling characteristic of the orbit in...

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Publicado en:Thyroid
Autores principales: Kumar, Seema, Coenen, Michael, Iyer, Seethalakshmi, Bahn, Rebecca S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc. 2015
Materias:
Immunology, Autoimmunity, and Graves' Ophthalmopathy
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589307/
https://ncbi.nlm.nih.gov/pubmed/26213859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2015.0254
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