Fingolimod induces neuroprotective factors in human astrocytes

BACKGROUND: Fingolimod (FTY720) is the first sphingosine-1-phosphate (S1P) receptor modulator approved for the treatment of multiple sclerosis. The phosphorylated active metabolite FTY720-phosphate (FTY-P) interferes with lymphocyte trafficking. In addition, it accumulates in the CNS and reduces bra...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Hoffmann, Franziska S., Hofereiter, Johann, Rübsamen, Heike, Melms, Johannes, Schwarz, Sigrid, Faber, Hans, Weber, Peter, Pütz, Benno, Loleit, Verena, Weber, Frank, Hohlfeld, Reinhard, Meinl, Edgar, Krumbholz, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589103/
https://ncbi.nlm.nih.gov/pubmed/26419927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-015-0393-6
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