Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration

Neurotrophin growth factors support neuronal survival and function. In this study, we show that the expression of the neurotrophin receptor TrkB is induced on astrocytes in white matter lesions in multiple sclerosis (MS) patients and mice with experimental autoimmune encephalomyelitis (EAE). Surpris...

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Hlavní autoři: Colombo, Emanuela, Cordiglieri, Chiara, Melli, Giorgia, Newcombe, Jia, Krumbholz, Markus, Parada, Luis F., Medico, Enzo, Hohlfeld, Reinhard, Meinl, Edgar, Farina, Cinthia
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302220/
https://ncbi.nlm.nih.gov/pubmed/22393127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20110698
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