Targeted activation of melanoma differentiation-associated protein 5 (MDA5) for immunotherapy of pancreatic carcinoma

The RIG-I-like helicase melanoma differentiation-associated protein 5 (MDA5) is an innate immune receptor for double-stranded viral RNA (dsRNA) that, upon activation, induces a Type I interferon (IFN)-driven immune response. In the present study, we demonstrate that human und murine pancreatic cance...

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Dettagli Bibliografici
Pubblicato in:Oncoimmunology
Autori principali: Duewell, Peter, Beller, Ebba, Kirchleitner, Sabrina V, Adunka, Tina, Bourhis, Helene, Siveke, Jens, Mayr, Doris, Kobold, Sebastian, Endres, Stefan, Schnurr, Max
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2015
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589065/
https://ncbi.nlm.nih.gov/pubmed/26504669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1029698
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