Dying cells expose a nuclear antigen cross-reacting with anti-PD-1 monoclonal antibodies

Checkpoint molecules such as programmed death 1 (PD-1) dampen excessive T cell activation to preserve immune homeostasis. PD-1-specific monoclonal antibodies have revolutionized cancer therapy, as they reverse tumour-induced T cell exhaustion and restore CTL activity. Based on this success, decipher...

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Udgivet i:Sci Rep
Main Authors: Metzger, Philipp, Kirchleitner, Sabrina V., Koenig, Lars M., Hörth, Christine, Kobold, Sebastian, Endres, Stefan, Schnurr, Max, Duewell, Peter
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995819/
https://ncbi.nlm.nih.gov/pubmed/29892077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-27125-6
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