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Breaking tumor-induced immunosuppression with 5′-triphosphate siRNA silencing TGFβ and activating RIG-I
Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor that is activated by 5′-triphosphate RNA molecules to induce type I interferon secretion and apoptosis in response to viral infection. We have designed a bifunctional small-interfering RNA that combines transforming growth fact...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3667904/ https://ncbi.nlm.nih.gov/pubmed/23762798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.24170 |
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