RIG-I-like helicases induce immunogenic cell death of pancreatic cancer cells and sensitize tumors toward killing by CD8(+) T cells

Pancreatic cancer is characterized by a microenvironment suppressing immune responses. RIG-I-like helicases (RLH) are immunoreceptors for viral RNA that induce an antiviral response program via the production of type I interferons (IFN) and apoptosis in susceptible cells. We recently identified RLH...

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Publicat a:Cell Death Differ
Autors principals: Duewell, P, Steger, A, Lohr, H, Bourhis, H, Hoelz, H, Kirchleitner, S V, Stieg, M R, Grassmann, S, Kobold, S, Siveke, J T, Endres, S, Schnurr, M
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
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Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227156/
https://ncbi.nlm.nih.gov/pubmed/25012502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.96
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