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Innate vs. Adaptive: PD-L1-mediated immune resistance by melanoma
Oncogenic driver mutations in several tumor types promote constitutive PD-L1 expression, a crucial ligand in PD-1-mediated tumor immune escape. Our studies in melanoma suggest a different mechanism–one of “adaptive immune resistance” in which PD-L1 expression is primarily driven by cytokine inductio...
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| Veröffentlicht in: | Oncoimmunology |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Taylor & Francis
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4589064/ https://ncbi.nlm.nih.gov/pubmed/26451298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1029704 |
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