Paucity of PD-L1 Expression in Prostate Cancer: Innate and Adaptive Immune Resistance

BACKGROUND: Primary prostate cancers are infiltrated with PD-1 expressing CD8+ T cells. However, in early clinical trials, men with mCRPC did not respond to PD-1 blockade as a monotherapy. One explanation for this unresponsiveness could be that prostate tumors generally do not express PD-L1, the pri...

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Detalhes bibliográficos
Publicado no:Prostate Cancer Prostatic Dis
Main Authors: Martin, Allison M., Nirschl, Thomas R., Nirschl, Christopher J., Francica, Brian J., Kochel, Christina M., van Bokhoven, Adrie, Meeker, Alan K., Lucia, M. Scott, Anders, Robert A., DeMarzo, Angelo M., Drake, Charles G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641011/
https://ncbi.nlm.nih.gov/pubmed/26260996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pcan.2015.39
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