The antitumor immune response generated by fractionated radiation therapy may be limited by tumor cell adaptive resistance and can be circumvented by PD-L1 blockade

Fractionated radiation therapy (RT) leads to adaptive changes in the tumor microenvironment that may limit the generation of an antitumor immune response. We demonstrated that fractionated RT led to increased tumor cell expression of programmed cell death ligand 1 (PD-L1) in response to CD8(+) T cel...

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Bibliografiske detaljer
Udgivet i:Oncoimmunology
Main Authors: Dovedi, S J, Illidge, T M
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485833/
https://ncbi.nlm.nih.gov/pubmed/26140246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1016709
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