Blockade of TNF-α signaling benefits cancer therapy by suppressing effector regulatory T cell expansion

Effector but not naive regulatory T cells (Treg cells) can accumulate in the peripheral blood as well as the tumor microenvironment, expand during tumor progression and be one of the main suppressors for antitumor immunity. However, the underlying mechanisms for effector Treg cell expansion in tumor...

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Publicado en:Oncoimmunology
Autores principales: Chang, Li-Yuan, Lin, Yung-Chang, Chiang, Jy-Ming, Mahalingam, Jayashri, Su, Shih-Huan, Huang, Ching-Tai, Chen, Wei-Ting, Huang, Chien-Hao, Jeng, Wen-Juei, Chen, Yi-Cheng, Lin, Shi-Ming, Sheen, I-Shyan, Lin, Chun-Yen
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2015
Materias:
Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589045/
https://ncbi.nlm.nih.gov/pubmed/26451304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1040215
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