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AAV9 supports wide-scale transduction of the CNS and TDP-43 disease modeling in adult rats

AAV9 has emerged as an efficient adeno-associated virus (AAV) serotype for gene transfer to the central nervous system. We have used this technique to study aspects of amyotrophic lateral sclerosis (ALS) by administering AAV encoding the ALS-related gene transactive response DNA binding protein of 4...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Jackson, Kasey L, Dayton, Robert D, Klein, Ronald L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588447/
https://ncbi.nlm.nih.gov/pubmed/26445725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2015.36
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