Expansive Gene Transfer in the Rat CNS Rapidly Produces Amyotrophic Lateral Sclerosis Relevant Sequelae When TDP-43 is Overexpressed

Improved spread of transduction in the central nervous system (CNS) was achieved from intravenous administration of adeno-associated virus serotype-9 (AAV9) to neonatal rats. Spinal lower motor neuron transduction efficiency was estimated to be 78% using the highest vector dose tested at a 12-week i...

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Detalhes bibliográficos
Main Authors: Wang, David B, Dayton, Robert D, Henning, Phillip P, Cain, Cooper D, Zhao, Li Ru, Schrott, Lisa M, Orchard, Elysse A, Knight, David S, Klein, Ronald L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997590/
https://ncbi.nlm.nih.gov/pubmed/20877346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.191
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