Versatile Somatic Gene Transfer for Modeling Neurodegenerative Diseases

Por Klein, Ronald L., Wang, David B., King, Michael A.
Publicado em 2009

The advent of AAV9 expands applications for brain and spinal cord gene delivery

Por Dayton, Robert D, Wang, David B, Klein, Ronald L
Publicado em 2012

AAV9 supports wide-scale transduction of the CNS and TDP-43 disease modeling in adult rats

Por Jackson, Kasey L, Dayton, Robert D, Klein, Ronald L
Publicado no Mol Ther Methods Clin Dev (2015)

Parkin is protective for substantia nigra dopamine neurons in a tau gene transfer neurodegeneration model

Por Klein, Ronald L., Dayton, Robert D., Henderson, Karen M., Petrucelli, Leonard
Publicado em 2006

Transcriptome analysis of a tau overexpression model in rats implicates an early pro-inflammatory response

Por Wang, David B., Dayton, Robert D., Zweig, Richard M., Klein, Ronald L.
Publicado em 2010

Pronounced microgliosis and neurodegeneration in aged rats after tau gene transfer

Por Klein, Ronald L., Dayton, Robert D., Diaczynsky, Cynthia G., Wang, David B.
Publicado em 2009

Tau gene transfer, but not alpha-synuclein, induces both progressive dopamine neuron degeneration and rotational behavior in the rat

Por Klein, Ronald L., Dayton, Robert D., Lin, Wen-Lang, Dickson, Dennis W.
Publicado em 2005

Genetic strategies to study TDP-43 in rodents and to develop preclinical therapeutics for amyotrophic lateral sclerosis

Por Wang, David B., Gitcho, Michael A., Kraemer, Brian C., Klein, Ronald L.
Publicado em 2011

Better Targeting, Better Efficiency for Wide-Scale Neuronal Transduction with the Synapsin Promoter and AAV-PHP.B

Por Jackson, Kasey L., Dayton, Robert D., Deverman, Benjamin E., Klein, Ronald L.
Publicado no Front Mol Neurosci (2016)

Corrigendum: Better Targeting, Better Efficiency for Wide-Scale Neuronal Transduction with the Synapsin Promoter and AAV-PHP.B

Por Jackson, Kasey L., Dayton, Robert D., Deverman, Benjamin E., Klein, Ronald L.
Publicado no Front Mol Neurosci (2016)

Methods and Tips for Intravenous Administration of Adeno-associated Virus to Rats and Evaluation of Central Nervous System Transduction

Por Grames, Mychal S., Jackson, Kasey L., Dayton, Robert D., Stanford, John A., Klein, Ronald L.
Publicado no J Vis Exp (2017)

Circulating Neprilysin Clears Brain Amyloid

Por Liu, Yinxing, Studzinski, Christa, Beckett, Tina, Murphy, M. Paul, Klein, Ronald L., Hersh, Louis B.
Publicado em 2010

Tau expression levels from various adeno-associated virus vector serotypes produce graded neurodegenerative disease states

Por Klein, Ronald L., Dayton, Robert D., Tatom, Jason B., Diaczynsky, Cynthia G., Salvatore, Michael F.
Publicado em 2008

AAV8, 9, Rh10, Rh43 Vector Gene Transfer in the Rat Brain: Effects of Serotype, Promoter and Purification Method

Por Klein, Ronald L, Dayton, Robert D, Tatom, Jason B, Henderson, Karen M, Henning, Phillip P
Publicado em 2007

FOCAL EXPRESSION OF MUTATED TAU IN ENTORHINAL CORTEX NEURONS OF RATS IMPAIRS SPATIAL WORKING MEMORY

Por Ramirez, Julio J., Poulton, Winona E., Knelson, Erik, Barton, Cole, King, Michael A., Klein, Ronald L.
Publicado em 2010

PET imaging in rats to discern temporal onset differences between 6-hydroxydopamine and tau gene vector neurodegeneration models

Por Klein, Ronald L., Dayton, Robert D., Terry, Tracee L., Vascoe, Chris, Sunderland, John J., Tainter, Kerrie H.
Publicado em 2009

Efficient Neuronal Gene Transfer with AAV8 Leads to Neurotoxic Levels of Tau or Green Fluorescent Proteins

Por Klein, Ronald L., Dayton, Robert D., Leidenheimer, Nancy J., Jansen, Karen, Golde, Todd E., Zweig, Richard M.
Publicado em 2005

A Spirulina-Enhanced Diet Provides Neuroprotection in an α-Synuclein Model of Parkinson's Disease

Por Pabon, Mibel M., Jernberg, Jennifer N., Morganti, Josh, Contreras, Jessika, Hudson, Charles E., Klein, Ronald L., Bickford, Paula C.
Publicado em 2012

Recombinant AAV9-TLK1B Administration Ameliorates Fractionated Radiation-Induced Xerostomia

Por Shanmugam, Prakash Srinivasan Timiri, Dayton, Robert D., Palaniyandi, Senthilnathan, Abreo, Fleurette, Caldito, Gloria, Klein, Ronald L., Sunavala-Dossabhoy, Gulshan
Publicado em 2013

Mimicking Aspects of Frontotemporal Lobar Degeneration and Lou Gehrig's Disease in Rats via TDP-43 Overexpression

Por Tatom, Jason B, Wang, David B, Dayton, Robert D, Skalli, Omar, Hutton, Michael L, Dickson, Dennis W, Klein, Ronald L
Publicado em 2009