Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action

The thiazide-sensitive NaCl cotransporter (NCC) is important for renal salt handling and blood-pressure homeostasis. The canonical NCC-activating pathway consists of With-No-Lysine (WNK) kinases and their downstream effector kinases SPAK and OSR1, which phosphorylate NCC directly. The upstream mecha...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Roy, Ankita, Al-Qusairi, Lama, Donnelly, Bridget F., Ronzaud, Caroline, Marciszyn, Allison L., Gong, Fan, Chang, Y.P. Christy, Butterworth, Michael B., Pastor-Soler, Núria M., Hallows, Kenneth R., Staub, Olivier, Subramanya, Arohan R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588284/
https://ncbi.nlm.nih.gov/pubmed/26241057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI75245
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