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Evidence for an Induced Conformational Change in the Catalytic Mechanism of Homoisocitrate Dehydrogenase for Saccharomyces cerevisiae: Characterization of the D271N Mutant Enzyme
Homoisocitrate dehydrogenase (HIcDH) catalyzes the NAD(+)-dependent oxidative decarboxylation of HIc to α-ketoadipate, the fourth step in the α-aminoadipate pathway responsible for the de novo synthesis of L-lysine in fungi. A mechanism has been proposed for the enzyme that makes use of a Lys-Tyr pa...
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| Pubblicato in: | Arch Biochem Biophys |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4587348/ https://ncbi.nlm.nih.gov/pubmed/26325079 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2015.08.016 |
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