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Hyperglycemia impairs left–right axis formation and thereby disturbs heart morphogenesis in mouse embryos
Congenital heart defects with heterotaxia are associated with pregestational diabetes mellitus. To provide insight into the mechanisms underlying such diabetes-related heart defects, we examined the effects of high-glucose concentrations on formation of the left–right axis in mouse embryos. Expressi...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4586861/ https://ncbi.nlm.nih.gov/pubmed/26351675 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1504529112 |
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