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Epiblast Ground State Is Controlled by Canonical Wnt/β-Catenin Signaling in the Postimplantation Mouse Embryo and Epiblast Stem Cells

Epiblast stem cells (EpiSCs) are primed pluripotent stem cells and can be derived from postimplantation mouse embryos. We now show that the absence of canonical Wnt/β-catenin signaling is essential for maintenance of the undifferentiated state in mouse EpiSCs and in the epiblast of mouse embryos. At...

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Bibliografische gegevens
Hoofdauteurs: Sumi, Tomoyuki, Oki, Shinya, Kitajima, Keiko, Meno, Chikara
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3653965/
https://ncbi.nlm.nih.gov/pubmed/23691040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063378
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