Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes

Protease-activated receptor 1 (PAR1) is a G protein–coupled receptor (GPCR) for thrombin and promotes inflammatory responses through multiple pathways including p38 mitogen-activated protein kinase signaling. The mechanisms that govern PAR1-induced p38 activation remain unclear. Here, we define an a...

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Publicat a:J Cell Biol
Autors principals: Grimsey, Neil J., Aguilar, Berenice, Smith, Thomas H., Le, Phillip, Soohoo, Amanda L., Puthenveedu, Manojkumar A., Nizet, Victor, Trejo, JoAnn
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2015
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586747/
https://ncbi.nlm.nih.gov/pubmed/26391660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201504007
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