PDK2-mediated alternative splicing switches Bnip3 from cell death to cell survival

Herein we describe a novel survival pathway that operationally links alternative pre-mRNA splicing of the hypoxia-inducible death protein Bcl-2 19-kD interacting protein 3 (Bnip3) to the unique glycolytic phenotype in cancer cells. While a full-length Bnip3 protein (Bnip3FL) encoded by exons 1–6 was...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Gang, Hongying, Dhingra, Rimpy, Lin, Junjun, Hai, Yan, Aviv, Yaron, Margulets, Victoria, Hamedani, Mohammad, Thanasupawat, Thatchawan, Leygue, Etienne, Klonisch, Thomas, Davie, James R., Kirshenbaum, Lorrie A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586742/
https://ncbi.nlm.nih.gov/pubmed/26416963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201504047
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