Impaired NF-κB signalling underlies cyclophilin D-mediated mitochondrial permeability transition pore opening in doxorubicin cardiomyopathy

AIMS: The chemotherapy drug doxorubicin (Dox) is commonly used for treating a variety of human cancers; however, it is highly cardiotoxic and induces heart failure. We previously reported that the Bcl-2 mitochondrial death protein Bcl-2/19kDa interaction protein 3 (Bnip3), is critical for provoking...

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Detalhes bibliográficos
Publicado no:Cardiovasc Res
Main Authors: Dhingra, Rimpy, Guberman, Matthew, Rabinovich-Nikitin, Inna, Gerstein, Jonathon, Margulets, Victoria, Gang, Hongying, Madden, Nicholas, Thliveris, James, Kirshenbaum, Lorrie A
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7177490/
https://ncbi.nlm.nih.gov/pubmed/31566215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvz240
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