Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling

Doxorubicin (DOX) is widely used for treating human cancers, but can induce heart failure through an undefined mechanism. Herein we describe a previously unidentified signaling pathway that couples DOX-induced mitochondrial respiratory chain defects and necrotic cell death to the BH3-only protein Bc...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Dhingra, Rimpy, Margulets, Victoria, Chowdhury, Subir Roy, Thliveris, James, Jassal, Davinder, Fernyhough, Paul, Dorn, Gerald W., Kirshenbaum, Lorrie A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4280597/
https://ncbi.nlm.nih.gov/pubmed/25489073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414665111
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