Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling

par Dhingra, Rimpy, Margulets, Victoria, Chowdhury, Subir Roy, Thliveris, James, Jassal, Davinder, Fernyhough, Paul, Dorn, Gerald W., Kirshenbaum, Lorrie A.
Publié dans Proc Natl Acad Sci U S A (2014)

Impaired NF-κB signalling underlies cyclophilin D-mediated mitochondrial permeability transition pore opening in doxorubicin cardiomyopathy

par Dhingra, Rimpy, Guberman, Matthew, Rabinovich-Nikitin, Inna, Gerstein, Jonathon, Margulets, Victoria, Gang, Hongying, Madden, Nicholas, Thliveris, James, Kirshenbaum, Lorrie A
Publié dans Cardiovasc Res (2020)

PDK2-mediated alternative splicing switches Bnip3 from cell death to cell survival

par Gang, Hongying, Dhingra, Rimpy, Lin, Junjun, Hai, Yan, Aviv, Yaron, Margulets, Victoria, Hamedani, Mohammad, Thanasupawat, Thatchawan, Leygue, Etienne, Klonisch, Thomas, Davie, James R., Kirshenbaum, Lorrie A.
Publié dans J Cell Biol (2015)

Reduction of myocardial ischaemia–reperfusion injury by inactivating oxidized phospholipids

par Yeang, Calvin, Hasanally, Devin, Que, Xuchu, Hung, Ming-Yow, Stamenkovic, Aleksandra, Chan, David, Chaudhary, Rakesh, Margulets, Victoria, Edel, Andrea L, Hoshijima, Masahiko, Gu, Yusu, Bradford, William, Dalton, Nancy, Miu, Phuong, Cheung, David Yc, Jassal, Davinder S, Pierce, Grant N, Peterson, Kirk L, Kirshenbaum, Lorrie A, Witztum, Joseph L, Tsimikas, Sotirios, Ravandi, Amir
Publié dans Cardiovasc Res (2019)

A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy

par Amgalan, Dulguun, Garner, Thomas P., Pekson, Ryan, Jia, Xiaotong F., Yanamandala, Mounica, Paulino, Victor, Liang, Felix G., Corbalan, J. Jose, Lee, Jaehoon, Chen, Yun, Karagiannis, George S., Sanchez, Luis Rivera, Liang, Huizhi, Narayanagari, Swathi-Rao, Mitchell, Kelly, Lopez, Andrea, Margulets, Victoria, Scarlata, Marco, Santulli, Gaetano, Asnani, Aarti, Peterson, Randall T., Hazan, Rachel B., Condeelis, John S., Oktay, Maja H., Steidl, Ulrich, Kirshenbaum, Lorrie A., Gavathiotis, Evripidis, Kitsis, Richard N.
Publié dans Nat Cancer (2020)