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Transient mitochondrial permeability transition mediates excitotoxicity in glutamate-sensitive NSC34(D) motor neuron-like cells

Excitotoxicity plays a critical role in neurodegenerative disease. Cytosolic calcium overload and mitochondrial dysfunction are among the major mediators of high level glutamate-induced neuron death. Here, we show that the transient opening of mitochondrial permeability transition pore (tMPT) bridge...

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Bibliografiske detaljer
Udgivet i:Exp Neurol
Main Authors: Liu, Xiaoyun, Xu, Shangcheng, Wang, Pei, Wang, Wang
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586369/
https://ncbi.nlm.nih.gov/pubmed/26024861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2015.05.010
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