Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation

While the molecular mechanisms promoting activation of the Nod-like Receptor (NLR) family member NLRP3 inflammasome are beginning to be defined, little is known about the mechanisms that regulate the NLRP3 inflammasome. Acute (up to 4 hours) LPS stimulation, followed by ATP is frequently used to act...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Gurung, Prajwal, Li, Bofeng, Subbarao Malireddi, R. K., Lamkanfi, Mohamed, Geiger, Terrence L., Kanneganti, Thirumala-Devi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4585974/
https://ncbi.nlm.nih.gov/pubmed/26412089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14488
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