Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression

Disruption of angiotensin II type 1 (AT(1)) receptor prolonged life span in mice. Since aging-related decline in skeletal muscle function was retarded in Atgr1a(−/−) mice, we examined the role of AT(1) receptor in muscle regeneration after injury. Administration of AT(1) receptor blocker irbesartan...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Yabumoto, Chizuru, Akazawa, Hiroshi, Yamamoto, Rie, Yano, Masamichi, Kudo-Sakamoto, Yoko, Sumida, Tomokazu, Kamo, Takehiro, Yagi, Hiroki, Shimizu, Yu, Saga-Kamo, Akiko, Naito, Atsuhiko T., Oka, Toru, Lee, Jong-Kook, Suzuki, Jun-ichi, Sakata, Yasushi, Uejima, Etsuko, Komuro, Issei
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4585890/
https://ncbi.nlm.nih.gov/pubmed/26571361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14453
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