Highly efficient CRISPR/Cas9-mediated transgene knockin at the H11 locus in pigs

Transgenic pigs play an important role in producing higher quality food in agriculture and improving human health when used as animal models for various human diseases in biomedicine. Production of transgenic pigs, however, is a lengthy and inefficient process that hinders research using pig models....

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Veröffentlicht in:Sci Rep
Hauptverfasser: Ruan, Jinxue, Li, Hegang, Xu, Kui, Wu, Tianwen, Wei, Jingliang, Zhou, Rong, Liu, Zhiguo, Mu, Yulian, Yang, Shulin, Ouyang, Hongsheng, Yanru Chen-Tsai, Ruby, Li, Kui
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4585612/
https://ncbi.nlm.nih.gov/pubmed/26381350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14253
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