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Impact of kinetic isotope effects in isotopic studies of metabolic systems

BACKGROUND: Isotope labeling experiments (ILEs) are increasingly used to investigate the functioning of metabolic systems. Some enzymes are subject to kinetic isotope effects (KIEs) which modulate reaction rates depending on the isotopic composition of their substrate(s). KIEs may therefore affect b...

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Pubblicato in:BMC Syst Biol
Autori principali: Millard, Pierre, Portais, Jean-Charles, Mendes, Pedro
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583766/
https://ncbi.nlm.nih.gov/pubmed/26410690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12918-015-0213-8
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