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Triple isotopic labeling and kinetic isotope effects: Exposing H-transfer steps in enzymatic systems

Kinetic isotope effect (KIE) studies can provide insight into the mechanism and kinetics of specific chemical steps in complex catalytic cascades. Recent results from hydrogen KIE measurements have examined correlations between enzyme dynamics and catalytic function, leading to a surge of studies in...

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Bibliografski detalji
Glavni autori: Sen, Arundhuti, Yahashiri, Atsushi, Kohen, Amnon
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3139694/
https://ncbi.nlm.nih.gov/pubmed/21688781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2003873
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