Plasmodium Infection Is Associated with Impaired Hepatic Dimethylarginine Dimethylaminohydrolase Activity and Disruption of Nitric Oxide Synthase Inhibitor/Substrate Homeostasis

Inhibition of nitric oxide (NO) signaling may contribute to pathological activation of the vascular endothelium during severe malaria infection. Dimethylarginine dimethylaminohydrolase (DDAH) regulates endothelial NO synthesis by maintaining homeostasis between asymmetric dimethylarginine (ADMA), an...

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Foilsithe in:PLoS Pathog
Main Authors: Chertow, Jessica H., Alkaitis, Matthew S., Nardone, Glenn, Ikeda, Allison K., Cunnington, Aubrey J., Okebe, Joseph, Ebonyi, Augustine O., Njie, Madi, Correa, Simon, Jayasooriya, Shamanthi, Casals-Pascual, Climent, Billker, Oliver, Conway, David J., Walther, Michael, Ackerman, Hans
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2015
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583463/
https://ncbi.nlm.nih.gov/pubmed/26407009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005119
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