Plasmodium Infection Is Associated with Impaired Hepatic Dimethylarginine Dimethylaminohydrolase Activity and Disruption of Nitric Oxide Synthase Inhibitor/Substrate Homeostasis

Inhibition of nitric oxide (NO) signaling may contribute to pathological activation of the vascular endothelium during severe malaria infection. Dimethylarginine dimethylaminohydrolase (DDAH) regulates endothelial NO synthesis by maintaining homeostasis between asymmetric dimethylarginine (ADMA), an...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Chertow, Jessica H., Alkaitis, Matthew S., Nardone, Glenn, Ikeda, Allison K., Cunnington, Aubrey J., Okebe, Joseph, Ebonyi, Augustine O., Njie, Madi, Correa, Simon, Jayasooriya, Shamanthi, Casals-Pascual, Climent, Billker, Oliver, Conway, David J., Walther, Michael, Ackerman, Hans
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583463/
https://ncbi.nlm.nih.gov/pubmed/26407009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005119
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