Plasmodium Infection Is Associated with Impaired Hepatic Dimethylarginine Dimethylaminohydrolase Activity and Disruption of Nitric Oxide Synthase Inhibitor/Substrate Homeostasis

Inhibition of nitric oxide (NO) signaling may contribute to pathological activation of the vascular endothelium during severe malaria infection. Dimethylarginine dimethylaminohydrolase (DDAH) regulates endothelial NO synthesis by maintaining homeostasis between asymmetric dimethylarginine (ADMA), an...

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Vydáno v:PLoS Pathog
Hlavní autoři: Chertow, Jessica H., Alkaitis, Matthew S., Nardone, Glenn, Ikeda, Allison K., Cunnington, Aubrey J., Okebe, Joseph, Ebonyi, Augustine O., Njie, Madi, Correa, Simon, Jayasooriya, Shamanthi, Casals-Pascual, Climent, Billker, Oliver, Conway, David J., Walther, Michael, Ackerman, Hans
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583463/
https://ncbi.nlm.nih.gov/pubmed/26407009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005119
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