A genetic approach to the generation of antibodies with enhanced catalytic activities.
A hydrolytic catalytic antibody, generated against a nitrophenyl phosphonate transition state analogue, has been cloned and expressed in Escherichia coli for use as a model system to demonstrate the feasibility of using genetic selections to enhance catalytic activity. Conditions were found that per...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1993
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45833/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8094556/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.4.1160 |
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