Significant improvement of oxidase activity through the genetic incorporation of a redox-active unnatural amino acid

While nature employs various covalent and non-covalent strategies to modulate tyrosine (Y) redox potential and pK (a) in order to optimize enzyme activities, such approaches have not been systematically applied for the design of functional metalloproteins. Through the genetic incorporation of 3-meth...

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Dades bibliogràfiques
Publicat a:Chem Sci
Autors principals: Yu, Yang, Zhou, Qing, Wang, Li, Liu, Xiaohong, Zhang, Wei, Hu, Meirong, Dong, Jianshu, Li, Jiasong, Lv, Xiaoxuan, Ouyang, Hanlin, Li, Han, Gao, Feng, Gong, Weimin, Lu, Yi, Wang, Jiangyun
Format: Artigo
Idioma:Inglês
Publicat: Royal Society of Chemistry 2015
Matèries:
Chemistry
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583198/
https://ncbi.nlm.nih.gov/pubmed/26417427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc01126d
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