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Inhibition of SCD1 impairs palmitate-derived autophagy at the step of autophagosome-lysosome fusion in pancreatic β-cells

Autophagy is indispensable for the proper architecture and flawless functioning of pancreatic β-cells. A growing body of evidence indicates reciprocal communication between autophagic pathways, apoptosis, and intracellular lipids. The way in which elevated levels of free saturated or unsaturated FAs...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Lipid Res
Prif Awduron: Janikiewicz, Justyna, Hanzelka, Katarzyna, Dziewulska, Anna, Kozinski, Kamil, Dobrzyn, Pawel, Bernas, Tytus, Dobrzyn, Agnieszka
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Biochemistry and Molecular Biology 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583082/
https://ncbi.nlm.nih.gov/pubmed/26293158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M059980
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