Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion

Lysosome is a key subcellular organelle in the execution of the autophagic process and at present little is known whether lysosomal function is controlled in the process of autophagy. In this study, we first found that suppression of mammalian target of rapamycin (mTOR) activity by starvation or two...

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Autori principali: Zhou, Jing, Tan, Shi-Hao, Nicolas, Valérie, Bauvy, Chantal, Yang, Nai-Di, Zhang, Jianbin, Xue, Yuan, Codogno, Patrice, Shen, Han-Ming
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616426/
https://ncbi.nlm.nih.gov/pubmed/23337583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2013.11
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