The oncogenic FIP1L1-PDGFRα fusion protein displays skewed signaling properties compared to its wild-type PDGFRα counterpart

Aberrant activation of oncogenic kinases is frequently observed in human cancers, but the underlying mechanism and resulting effects on global signaling are incompletely understood. Here, we demonstrate that the oncogenic FIP1L1-PDGFRα kinase exhibits a significantly different signaling pattern comp...

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Veröffentlicht in:JAKSTAT
Hauptverfasser: Haan, Serge, Bahlawane, Christelle, Wang, Jiali, Nazarov, Petr V, Muller, Arnaud, Eulenfeld, René, Haan, Claude, Rolvering, Catherine, Vallar, Laurent, Satagopam, Venkata P, Sauter, Thomas, Wiesinger, Monique Yvonne
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2015
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583054/
https://ncbi.nlm.nih.gov/pubmed/26413425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21623996.2015.1062596
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